Usual cause
Allergy to plasma proteins, rarely to donor medication etc.
Incidence
1-3% of plasma infusions (1).
Main clinical features
Usually pruritic urticarial lesions, but may also include wheezing or angioedematous reactions.
Investigation
Usually none.
Intervention
Stop or slow transfusion. Give antihistamine. In severe cases consider corticosteroids or adrenaline. Consider Emergency team/MET call
Transfusion can be slowly continued when the reaction abates. Consider premedication and/or washed cells if recurrent.