| Standard blood giving set incorporating filter (170-200 µm) | To filter out large clots and aggregates and to ensure an effective transfusion flow rate. Most standard blood filters are designed to filter 2-4 units of blood, however each giving set should be changed at least 8 hourly or earlier if flow rates are compromised. | Should be used in the transfusion line for all blood components.
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| Microaggregate filter (20-40 µm) | To filter out microaggregates consisting of fibrin, leucocytes and platelets in red cell components. May be used for other components according to the manufacturer’s instructions.
| There is insufficient evidence to recommend the routine use of microaggregate filters. These filters may be of benefit in massive, rapid transfusion (however the flow rate may be slowed) or in patients with compromised circulation. The product insert should be consulted to determine if use in conjunction with a pump is acceptable. |
Pre-storage leucocyte depletion filters
- platelets
- red cells | To remove contaminating leucocytes to < 1 x 10^6 /unit and thereby also reduce cytokine accumulation and minimise the storage lesion. Pre-storage leucocyte depletion may be achieved by an in-process collection step or filtration soon after collection. Pre-storage leucocyte depleted blood components do not require further bedside leucodepletion, however, still require transfusion through a standard blood giving set incorporating a 170- 200 micron filter. | Established indications are listed on page 77 of TMM All red cells produced by ARCBS in SA, WA, ACT, NT, Vic and Tas will be leucodepleted from 1 July 2008 and NSW and Queensland from 1 October 2008. All platelets produced by ARCBS have been leucodepleted since 28 April 2008. |